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04 Nov

Are Oral Health Issues Genetic?

Are oral health issues genetic? The short answer is: some are, some aren’t. Heredity can indeed play a contributing role in some oral conditions. But the American Dental Association (ADA) notes that there are currently no genetic tests for the two most common dental diseases, dental caries (tooth decay) and gum disease. However, there are other conditions that do have a genetic component.

Genetic Oral Abnormalities

According to the textbook Clinical Embryology: An Atlas of Congenital Malformations, tooth development begins at about 30 days in the gestational process and typically ends by age 19, when wisdom teeth erupt. During this period, developmental dental issues can arise. These are some of the genetic defects affecting the oral cavity:

  • AnodontiaAnodontia is the complete absence of teeth and is extremely rare.
  • HypodontiaHypodontia, or partial anodontia, describes when an individual is missing one to five teeth from birth (not including wisdom teeth). The most common missing teeth are second premolars and lateral incisors. This is the most common dental genetic abnormality, affecting 1 in 18 people.
  • Amelogenesis ImperfectaThis disorder results in defective or missing enamel, which is the outer protective layer of the teeth. It may also cause malocclusion, or misalignment. It affects only 1 in 7,000 to 14,000 people.
  • Dentinogenesis ImperfectaThis condition causes tooth discoloration or the appearance of translucency, as the National Institutes of Health (NIH) explains. The teeth are also typically weaker and more prone to breakage.
  • Cleft Lip and PalateThese are oral malformations that occur during the development of the fetus. The result is improper formation of the roof of the mouth, the lips or both, notes the NIH.

Other Hereditary Conditions that Can Affect Oral Health

While those genetic abnormalities specifically affect the teeth and mouth, there are many other hereditary systemic conditions that can have ripple effects in the oral cavity, as reported in the Shiraz University of Medical Sciences Journal of Dentistry:

  • Down SyndromeDown syndrome can also be associated with macroglossia, which is an enlarged tongue, delayed eruption of teeth and partial anodontia.
  • Klinefelter SyndromeKlinefelter syndrome can be related to cleft palate, missing premolars and delayed development of the permanent tooth germs.
  • Apert SyndromeThis condition can involve an open bite in the front teeth, malocclusion, delayed tooth eruption and crowding of the teeth.
  • Mohr SyndromePeople who have this syndrome may have cleft palate, a small tongue or notching of the upper lip.
  • Tricho-Dento-Osseous SyndromeThe dental characteristics of this syndrome include hypoplastic or poorly formed enamel.

So, are oral health issues genetic?

The final answer is, sometimes — depending on the issue. Certain developmental oral conditions indeed stem from genes, and other hereditary conditions that affect the body can subsequently affect the teeth and the oral cavity.